Cisplatin, nephrotoxicity, nephroprotection, matricaria chamomilla, nigella sativa, vitamin e. Oct 10, 2019 long aristolochia aristolochia longa industrial crops and products. P glycoprotein contributes substantially to ciclosporin nephrotoxicity. Over the years, it has become increasingly evident that lowlevel lead exposure resulting in blood lead levels between 10 and 15. Breast malignant neoplastic disease is one of the most complex diseases, as it is a multifactorial disease in which virtually all the targets are instantly or indirectly interreliant on each other. An excess of nitrogen compounds in the blood may lead to uremia. Nephrotoxins are substances displaying nephrotoxicity nephrotoxicity should not be confused with the fact that some medications are. Mechanisms of antimicrobialinduced nephrotoxicity in. Acute nephrotoxicity of tacrolimus and sirolimus in renal is. In view of this, the present work was undertaken to study detailed biochemical eventscellular responsemechanisms of sodium arsenate naas nephropathy and its possible mitigation. Nanoscale research letters acute and chronic nephrotoxicity of platinum nanoparticles in mice yoshiaki yamagishi 0 akihiro watari 0 yuya hayata 0 xiangru li 0 masuo kondoh 0 yasuo yoshioka 1 yasuo tsutsumi 1 kiyohito yagi 0 0 laboratories of biofunctional molecular chemistry, graduate school of pharmaceutical sciences, osaka university, suita, osaka 5650871, japan 1 laboratories of. Acute and chronic nephrotoxicity of platinum nanoparticles.
Puerarin was administrated through caudal vein injection once per day at the dose of 10mgkg, 30mgkg and 50mgkg. Chronic lead nephrotoxicity consists of interstitial fibrosis and progressive nephron loss, azotaemia and renal failure. Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who received cisplatin combination chemotherapy. Our current knowledge of drug induced kidney disease is limited due to varying definitions of kidney injury, incomplete assessment of concurrent risk factors and lack of long term outcome reporting. Use of trade names is for identification only and does not imply endorsement by the agency for toxic substances and disease registry, the public health service, or the u. The aim of the present study is to clarify the possible corrective role of curcumin on the nephrotoxicity induced by lead acetate. Erythrophagocytosis of leadexposed erythrocytes by renal tubular cells.
Lead acetate nephrotoxicity, glomerular blood flow, oxidative stress, low viscosity sodium alginate, proximal convoluted tubules. Lead is one of the most useful elements in industry, but serves no useful function in the human body. However, experimental evidence supporting these claims in transplant models is lacking. Curcumin ameliorates cisplatininduced nephrotoxicity and. Adults the neurological effects in an adult exposed to lead as an adult can be neuropathy, and may be different from those of an adult exposed to lead as a child when the brain was developing more information for adults in following sections. June 12, 2021 download printerfriendly version adobe pdf file pdf 1. Thus, it is highly desirable to develop a reliable model to evaluate cdinduced nephrotoxicity in vitro. Lead nephropathy and leadrelated nephrotoxicity uptodate. Leadinduced chronic renal failuredefinitionlead pb nephrotoxicity relates to experimental, epidemiologic, and clinical evidence of renal damage and hypertension associated to environmental or occupational pb exposure. Cadmium cadmium exposure sources nephrotoxicity caused by cadmium has been. Druginduced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in hospitalized patients and is associated with increased morbidity and mortality in both children and adults. Druginduced nephrotoxicity is one of the leading causes of aki worldwide. Druginduced nephrotoxicity analysis in hiv therapy. We subsequently studied the effect of ondansetron treatment on cisplatin induced nephrotoxicity in mice.
We aimed to explore the potential protective impacts of coenzyme q10 coq10 on lead acetate pbacinduced nephrotoxicity in rats. Therefore, careful medical supervision is required and dose and dose schedule must be adjusted to the individual patients needs. Ondansetron alone did not show any toxicity in mice during our toxicity study fig. This study assesses the acute nephrotoxicity of tac and sir in renal transplants by using a rat isograft model. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function.
Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4dependent very low. The degree of vancomycininduced renal dysfunction is usually modest, with a typical decrease of 3545% in creatinine clearance from baseline. Cell proliferation in rat kidney induced by lead acetate and effects of uninephrectomy on the proliferation. Goyer department of pathology, university of western ontario, london, ontario, n6a 5c1 canada summary exposure to lead results in accumulation in proximal renal tubular lining cells in the form of mor phologically discernible inclusion bodies which are lead. Pdf lead induced nephrotoxicity with special reference to. Pathophysiological abnormalities include changes in intraglomerular hemodynamics, tubular. Ondansetron can enhance cisplatininduced nephrotoxicity via. You can also locate patient education articles on a variety of subjects by searching on patient info and the keyword s of interest. The prediction of proximal tubular toxicity during drug development remains. As the list of drugs, natural products, industrial chemicals and environmental pollutants that cause nephrotoxicity has increased, it has. Cilastatin protects against imipeneminduced nephrotoxicity. Its effects on human health have attracted great attention.
Health canada has conducted an assessment of the most current science on lead and consolidated the information in a state of the science report. Efforts to prevent andor slow progression of ckd are essential. Drug induced kidney injury is a frequent adverse event which contributes to morbidity and increased healthcare utilization. Lead pb toxicity remains a significant public health problem because of its global pervasiveness and its adverse effects on the renal system. Nov 15, 20 ondansetron may enhance cisplatin induced nephrotoxicity via inhibition on mate1 in mice. Acute tubular necrosis atn is the most common cause of acute kidney failure 90%. Pdf lead pollution is one of the most important problems of environmental and occupational origin and is widely regarded as risk to health. While the purpose of most medications is to heal the body, sometimes adverse reactions may occur.
The 2009 version of the vancomycin consensus guidelines defines vancomycininduced nephrotoxicity based on an increase in serum creatinine of 0. The results suggest that lead acetateinduced nephrotoxicity by induction of oxidative stress and disruption of antioxidant. It must be emphasized that there is no known blood lead level for children without some level of risk for some of the adverse neurological effects of lead in children. Finally, determination of a patients or donors genotype of drugmetabolizing genes or of mol ecules involved in csa nephrotoxicity, like tgf. In addition to causing aki, chronic drug toxicity can, in some cases, lead to ckd and eventual endstage renal disease. Leadinduced chronic renal failuredefinitionlead pb nephrotoxicity relates to experimental, epidemiologic. Nephrotoxicity definition of nephrotoxicity by medical. Previous reports investigated the role of puerarin in lead induced chronic nephrotoxicity 27, 28. If unchecked, the kidney failure may lead to the death. Chronic kidney disease ckd represents a major global public health concern. Lead has many good uses, but too much can be harmful to humans and animals. Nacetylcysteine rescue protocol for nephrotoxicity in children caused by ifosfamide. Simultaneous determination of five specific and sensitive. The onset of vancomycin nephrotoxicity typically ranges from three to eight days from the start of therapy.
Antimicrobials are one of the most common classes of medications prescribed globally and also among the most common causes of nephrotoxicity. The kidney is among the metabolic organs most susceptible to injury, particularly following exposure to xenobiotics and heavy metals. Drug induced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in hospitalized patients and is associated with increased morbidity and mortality in both children and adults. Renoprotection of urinederived stem cells in a chronic. The clinical diagnosis of lead nephropathy is complex, because the symptoms are varied and nonspecific especially with subclinical nephrotoxicity. In present study effect of puerarin on cisplatin nephrotoxicity was evaluated. The high level of lead exposure required to cause lead nephropathy is now increasingly rare, particularly in developed countries, due to occupational controls and removal of lead from paint, gasoline, and other environmental sources figure 1. The effect of nacetylcysteine on ifosfamideinduced nephrotoxicity. Nephroprotective effect of costus afer on lead induced kidney damage in albino rats. Nephroprotective effect of nigella sativa and matricaria. However, severe renal toxicity has been associated with vancomcyin. Full text druginduced impairment of renal function ijnrd.
Chronic lead exposure has been implicated in renal failure in. Lead poisoning and gout are two of the most ancient diseases known to medicine. There are various forms, and some drugs may affect kidney function in more than one way. We aimed to explore the potential protective impacts of coenzyme q10 coq10 on lead acetate pbac induced nephrotoxicity in rats. Classified as nephropathies are nephropathy of pregnancy and a group of other kidney diseases that are distinguished from each other by a variety of morphological changes. Figure6 various sites of the drug induced nephrotoxicity the nephrotoxic substances causes nephrotoxicity. Erythrophagocytosis of leadexposed erythrocytes by renal. Introduction the use of plants in medicine is an agelong practice in various parts of the globe for both timated that about 80% of the world population relies on. Oxidative stress plays a key role in lead induced nephrotoxicity. Creatinine is concluded as a good safety marker in 25 studies, with a total sample size of 4789 patients with a clear association with drug induced nephrotoxicity in hiv patients of all the antiretroviral drugs used to treat hiv, tenofovir either as a monotherapy or in combination with other drugs induced nephrotoxicity as evaluated by the. Causes of ckd vary widely, however drug induced nephrotoxicity has been an increasingly recognized complication of many therapeutic agents in the clinical setting. The 6rs of drug induced nephrotoxicity bmc nephrology. These include lead s ability to inhibit or mimic the actions of calcium which can affect calciumdependent or related processes and to interact with proteins including those with sulfhydryl, amine, phosphate, and carboxyl groups atsdr 2010. Their results demonstrated that puerarin could attenuate lead caused renal cells apoptosis and morphologic damages via modulating pi3kaktenos pathway 27, 28.
Environmental and industrial lead exposures continue to pose major public health problems in the exposed population. In clinical diagnosis, serum creatinine cr was commonly used as the routine markers for the evaluation of kidney injury. Full text is available as a scanned copy of the original print version. Effect of green coffee on cisplatin induced renal apoptosis. Four experimental groups n 7 were applied as follows.
Lead pb is a naturally occurring element found in rock and soil, yet widespread anthropogenic use. Recent evidence has demonstrated that patients with chronic kidney disease ckd have an increased risk of developing acute kidney injury aki. Nephrotoxicity definition of nephrotoxicity by the free. Aki biomarker cutoffs for diagnosis, outcome prediction and aki stratification increased in the presence of albuminuria. Addiction to opioids can lead to kidney injury in various ways, such as acute glomerulonephritis caused by blood borne infection from contaminated needles and aki caused by nontraumatic rhabdomyolysis. To investigate the specific and sensitive nephrotoxicity biomarkers in different druginduced kidney injury dki models, receiver operating characteristic roc analysis was applied in this study. Links to pubmed are also available for selected references. Nephroprotective effect of costus afer on lead induced kidney. Nephrotoxicity renal toxicity managing side effects. Some of the reason for this is that chronic renal disease from lead exposure does not become evident until late in life and usually after many years of excessive exposure. Basics topic beyond the basics topic other sources of accurate you can also locate patient education.
Chronic nephropathy is one of the oldest recognized health effects of lead. Edelweiss applied science and technology, 2018 pdf. Fahmy 3 1 department of physiology, faculty of medicine, alazhar university, assuit, egypt. Indian journal of occupational and environmental medicine december 2008 volume 12 issue 3. In present study puerarin was studied in cisplatin nephrotoxicity, a frequent. The kidney is the organ that is the most affected by cd exposure.
More side effects increased nephrotoxicity change in the drug metabolism 4. This may lead to overdiagnosis of aki in conditions independently associated with proteinuria. Lead toxicity what are possible health effects from lead exposure. Neuroprotective potential of indigofera oblongifolia leaf. Pathophysiology of nephrotoxic acute renal failure h umans are exposed intentionally and unintentionally to a variety of diverse chemicals that harm the kidney. Our current knowledge of drug induced kidney disease is limited due to varying definitions of kidney. C 7, 10, 32, 48 druginduced renal impairment is generally reversible, provided the nephrotoxicity is recognized early and the offending medication is discontinued. Nephrotoxicity induced by drugs among older adults may reach as high as 66% bellomo 2006. It can happen if lead builds up in your body, usually over many months or years. The 6rs of drug induced nephrotoxicity linda awdishu1,2 and ravindra l. Relationship between various biological exposure indices and early markers of nephrotoxicity, american journal of industrial medicine on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Renal effects of environmental and occupational lead exposure. Toxicology letters, 46 1989 153162 153 txl 02127 mechanisms of lead and cadmium nephrotoxicity r.
Acute and chronic nephrotoxicity of platinum nanoparticles in. However, prolonged lead exposure at the lower levels encountered in developed countries may still contribute to kidney toxicity, an association that has been referred to as leadrelated nephrotoxicity. Lead poisoning can be harmful in adults, but is especially harmful in children because. A number of factors have been identified as adding risk to the development of tdfinduced nephrotoxicity including advanced age, low body mass index. Mechanisms of lead and cadmium nephrotoxicity sciencedirect. The tt genotype at the abcb1 3435ct polymorphism is associated with. Lasix can increase the risk of cephalosporininduced nephrotoxicity even in the setting of. Lead induced chronic renal failuredefinitionlead pb nephrotoxicity relates to experimental, epidemiologic, and clinical evidence of renal damage and. Protective effects of spirulina maxima on hyperlipidemia and.
Patients at risk common risk factors for druginduced nephrotoxicity are underlying kidney disease, age older than 60 years, diabetes mellitus, heart disease, intravascular volume depletion, and multiple nephrotoxic drugs. Drugs toxic to kidneys, nephrotoxicity in dogs dogs. In patients with preexisting renal dysfunction or renal ischemia, the effects of drug induced nephrotoxicity can be profound and may accelerate progression to esrd 2. Acute nephrotoxicity consists of proximal tubular dysfunction and can be reversed by treatment with chelating agents.
Prediction of druginduced nephrotoxicity and injury. Lead exposure and kidney function national kidney foundation. The period of lead intoxication extended for 3 months followed by either 1 month treatment with garlic and silymarin or 5 days treatment with dmsa. Nephrotoxic atn is usually associated with the proximal tubules 3. Lead poisoning is a type of metal poisoning caused by lead in the body. Final human health state of the science report on lead. Nephrotoxicity results from lead exposure because the kidney is the main route by which lead is eliminated.
Nephrotoxicity and agents responsible nephrotoxic injury is damage to one or both kidenys that result from exposure to a toxic substance. Lead pb is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. In this condition the kidney function deteriorates and may lead to chronic kidney failure. See lead exposure and poisoning in adults and childhood lead. Warning lasix furosemide is a potent diuretic which, if. Despite everything, its clinical use is limited, due to. This study was conducted to compare the curative role of garlic combined with silymarin versus dimercaptosuccinic acid dmsa in decreasing lead induced nephrotoxicity in adult male albino rats. Jun 12, 2017 on a molecular level, proposed mechanisms for toxicity involve fundamental biochemical processes. Nephrotoxins are chemicals displaying nephrotoxicity. Potential complications of lead nephropathy include gout and hypertension. Lead is a natural element found in small amounts in the earth. Puerarin attenuates cisplatininduced rat nephrotoxicity. Effect of green coffee on cisplatin induced renal apoptosis in adult male albino rats ahmed elsayed nour eldeen 1, abd elmegeed mansour 1, ahmad taha 2, ehab m. Creatinine is concluded as a good safety marker in 25 studies, with a total sample size of 4789 patients with a clear association with druginduced nephrotoxicity in hiv patients of all the antiretroviral drugs used to treat hiv, tenofovir either as a monotherapy or in combination with other drugs induced nephrotoxicity as evaluated by the.
The distinctive colic followed by palsy was characterized by nikander in the second century b. Deltamethrin, nephrotoxicity, basil, oxidative stress. By continuing to browse this site you are agreeing to our use of cookies. Rat model of nephrotoxicity was established by a single intraperitoneal injection of cisplatin 7mgkg. This is most likely to occur in patients who have chronic kidney disease ckd or are at risk because of diabetes mellitus or hypertension. The renal proximal tubule is a main target for druginduced toxicity. Symptoms may include abdominal pain, constipation, headaches, irritability, memory problems, inability to have children, and tingling in the hands and feet. To investigate the specific and sensitive nephrotoxicity biomarkers in different drug induced kidney injury dki models, receiver operating characteristic roc analysis was applied in this study. With acute lead nephrotoxicity, these leadprotein complexes are observed as typical intracellular inclusions. An update on leadrelated nephrotoxicity journal of renal. Nephrotoxicity is one of the most common kidney problems and occurs when your body is exposed to a drug or toxin that causes damage to your kidneys. Csaindependent risk of chronic renal failure following transplantation. Puerarin was a major isoflavonoid derived from the chinese medical herb radix puerariae gegen. Kidneys were examined on day 14 by routine histology and immunohistochemistry for transforming growth factor tgf.
Oxidative stress plays a key role in leadinduced nephrotoxicity. Nephrotoxicity of cisplatin combination chemotherapy in. Using solvents with different polarities allow the extraction of a selected group of antioxidants, affecting the antioxidant capacity estimation secondary causes of bone loss are factors other than menopause and aging that can lead to osteoporosis 18. Get a printable copy pdf file of the complete article 3. Nanoscale research letters acute and chronic nephrotoxicity of platinum nanoparticles in mice yoshiaki yamagishi 0 akihiro watari 0 yuya hayata 0 xiangru li 0 masuo kondoh 0 yasuo yoshioka 1 yasuo tsutsumi 1 kiyohito yagi 0 0 laboratories of biofunctional molecular chemistry, graduate school of pharmaceutical sciences, osaka university, suita, osaka 565. Nephrotoxicity and tubular necrosis can cause intrarenal failure which causes damage to the kidney tissues and structures. Solubility, amino acid content, and relationship to residual acidic nuclear proteins. Exposure to lead results in accumulation in proximal renal tubular lining cells in the form of morphologically discernible inclusion bodies which are leadprotein complexes. Whilst the ability of lithium to cause nephrogenic diabetes insipidus is well established, its ability to cause chronic kidney disease is a much more vexing issue, with various studies suggesting both. Rats were fed a diet containing glycine 5% or a control diet for 3 days before cyclosporine treatment. It causes almost 10% of intellectual disability of otherwise unknown cause and can result in behavioral problems. Frontiers coenzyme q10 activates the antioxidant machinery. In contrast to renal injury by land animal toxins which is due to hemodynamic changes and inflammatory reactions, nephrotoxicity induced by marine toxins is operated through enzymes, ion channels and pore transport.
Albuminuria was associated with paraquat induced nephrotoxicity and increased excretion of lowmolecular weight protein biomarkers. The term nephrotoxicity simply means toxic to the kidneys,therefore nephrotoxicty in dogs depicts the toxic effect that some substances and medications have on the dogs kidneys. Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast induced nephropathy amacing. When kidney damage occurs, you are unable to rid your body of excess urine, and wastes. It implies impairment in renal function an increase in serum creatinine by 25% or 0. Lasix furosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Most of these definitions allow for classification based on serum creatinine or urine output as a surrogate for the diagnosis of kidney injury. Ciclosporin nephrotoxicity leads to impaired renal function and chronic allograft nephropathy, which is a major predictor of graft loss.
The current study was carried out to evaluate the antioxidant activity of spirulina maxima against lead acetate induced hyperlipidemia and. Lvsa significantly attenuated leadinduced nephrotoxicity. Nephrotoxicityinduced proteinuria increases biomarker. Nacetylcysteine prevents ifosfamideinduced nephrotoxicity in rats. Lead acetate induced nephrotoxicity in wistar albino rats. Druginduced kidney diseases np singh, a ganguli, a prakash abstract druginduced kidney disease constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Despite lithium being the most efficacious treatment for bipolar disorder, its use has been decreasing at least in part due to concerns about its potential to cause significant nephrotoxicity. Efficacy of curcumin on lead induced nephrotoxicity in.
Lead is absorbed by the proximal tubular cells of the renal tubules, where it binds to specific leadbinding proteins. Chronic lead exposure can affect a variety of organ systems, including the kidney, where it can produce lead nephropathy, a chronic interstitial nephritis. Role of cadmium and lead in nephrotoxicity edelweiss publications. Felix braun, matthias behrend, in side effects of drugs annual, 2008. Nephrotoxicity by most plankton toxins is subclinical dietl and volke, 1994. This study investigated the possible neuroprotective role of indigofera oblongifolia leaf methanolic extract iolme against lead induced neurotoxicity. Assessment of cadmiuminduced nephrotoxicity using a. Original article nephroprotective effect of low viscosity. Lead nephropathy article about lead nephropathy by the. Drugs can also interfere with normal transport mechanisms in the kidney, leading to a variety of electrolyte and acidbase disorders. Hepatotoxicity in rats was induced by the method described previously 8 where 1 0. Cisplatin cis, an inorganic antineoplastic agent is widely utilized in the treatment of various solid tumors including breast cancer. Previous studies have shown the antioxidant effect of spirulina maxima in several experimental models of oxidative stress. Besides the histology change, imp treatment induced renal dysfunction.
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